Title : Inhibition of human cytochrome P450 3A4 by cholesterol.

Pub. Date : 2011 May 27

PMID : 21471209






1 Functional Relationships(s)
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1 Cholesterol inhibited the P450 3A4-catalyzed oxidations of nifedipine and quinidine, two prototypic substrates, in liver microsomes and a reconstituted enzyme system with K(i) ~ 10 muM in an apparently non-competitive manner. Nifedipine latexin Homo sapiens