Title : Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1.

Pub. Date : 2011 May 27

PMID : 21471201






1 Functional Relationships(s)
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Protein Name
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1 SIRT1 physically interacts with the mTOR-Raptor complex, and a single amino acid substitution in the TOS (TOR signaling) motif in the SIRT1 prevented Ser-47 phosphorylation and Bfl-1/A1 induction. tos mechanistic target of rapamycin kinase Homo sapiens