Pub. Date : 2011 Jul
PMID : 21468663
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed that etoposide treatment activated caspase-8 and caspase-3, leading to cleavages of p53, Bid and PARP, which subsequently induced apoptosis. | Etoposide | tumor protein p53 | Homo sapiens |
| 2 | Furthermore, p53 and Bid were accumulated in cytoplasm following etoposide treatment. | Etoposide | tumor protein p53 | Homo sapiens |
| 3 | Moreover, the pretreatment with trichostatin A (TSA, a histone deacetylase inhibitor) or TSA in combination with etoposide significantly sensitized HCC cells to apoptosis by inhibiting ERK phosphorylation, reactivating caspases and PARP, and inducing translocation of p53 and Bid to cytoplasm. | Etoposide | tumor protein p53 | Homo sapiens |