Title : Garcinol inhibits cell proliferation and promotes apoptosis in pancreatic adenocarcinoma cells.

Pub. Date : 2011

PMID : 21462088






1 Functional Relationships(s)
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1 The molecular mechanism of garcinol"s action on PaCa cells was investigated by targeting signaling moieties involved in apoptosis (X-IAP, cIAP, caspase-3, 9, and PARP cleavage), transcription factor NF-kappaB, believed to contribute toward a chemoresistance phenotype in pancreatic tumors, and molecules associated with neovascularization and metastasis (MMP-9, VEGF, IL-8, and PGE(2)). garcinol vascular endothelial growth factor A Homo sapiens