Pub. Date : 1990 Dec
PMID : 2146139
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin 3 induces histamine synthesis in the human hemopoietic system. | Histamine | interleukin 3 | Homo sapiens |
| 2 | Recombinant human interleukin 3 (rhIL-3) induces an increase in histamine production by human bone marrow, fetal liver, and cord blood cells. | Histamine | interleukin 3 | Homo sapiens |
| 3 | It results from an increase in histamine synthesis because of 1) the low level of histamine cell content before any incubation, 2) the parallel increase in both extra- and intracellular histamine levels in response to rhIL-3, and 3) the early IL-3-induced increase in L-histidine decarboxylase (HDC; EC 4.1.1.22) activity. | Histamine | interleukin 3 | Homo sapiens |