Title : Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.

Pub. Date : 2011 May 15

PMID : 21460187






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 dbcAMP-induced Rac1 activation was principally mediated by protein kinase A (PKA) and Sif- and Tiam1-like exchange factor (STEF)/Tiam2. Bucladesine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
2 dbcAMP-induced Rac1 activation was principally mediated by protein kinase A (PKA) and Sif- and Tiam1-like exchange factor (STEF)/Tiam2. Bucladesine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
3 PKA phosphorylates STEF at three residues (Thr-749, Ser-782, Ser-1562); Thr-749 phosphorylation was critical for dbcAMP-induced Rac1 activation and neurite extension. Bucladesine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus
4 During dbcAMP-induced neurite outgrowth, PKA activation at the plasma membrane became localized to neurite tips; this localization may contribute to local Rac1 activation at the same neurite tips. Bucladesine protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus