Title : Differentiated human colorectal cancer cells protect tumor-initiating cells from irinotecan.

Pub. Date : 2011 Jul

PMID : 21459094






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of the drug-efflux pump ABCB1 by PSC-833 allowed irinotecan to eradicate tumor-initiating cells. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
2 CONCLUSIONS: The resistance of colorectal tumors to irinotecan requires the cooperative action of tumor-initiating ALDHhigh/ABCB1negative cells and their differentiated, drug-expelling, ALDHlow/ABCB1positive daughter cells. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens
3 CONCLUSIONS: The resistance of colorectal tumors to irinotecan requires the cooperative action of tumor-initiating ALDHhigh/ABCB1negative cells and their differentiated, drug-expelling, ALDHlow/ABCB1positive daughter cells. Irinotecan ATP binding cassette subfamily B member 1 Homo sapiens