Pub. Date : 2011 Jul
PMID : 21459094
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the drug-efflux pump ABCB1 by PSC-833 allowed irinotecan to eradicate tumor-initiating cells. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | CONCLUSIONS: The resistance of colorectal tumors to irinotecan requires the cooperative action of tumor-initiating ALDHhigh/ABCB1negative cells and their differentiated, drug-expelling, ALDHlow/ABCB1positive daughter cells. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: The resistance of colorectal tumors to irinotecan requires the cooperative action of tumor-initiating ALDHhigh/ABCB1negative cells and their differentiated, drug-expelling, ALDHlow/ABCB1positive daughter cells. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |