Title : Inhibition of p53 DNA binding function by the MDM2 protein acidic domain.

Pub. Date : 2011 May 6

PMID : 21454483






1 Functional Relationships(s)
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1 Furthermore, we show that the MDM2 inhibitor Nutlin cooperates with the proteasome inhibitor Bortezomib by stimulating p53 DNA binding and transcriptional activity, providing a rationale for combination therapy using proteasome and MDM2 inhibitors. Bortezomib tumor protein p53 Homo sapiens