Title : [Activation of "silent" vasoconstrictive 5-HT1A receptors as a possible mechanism of synergism in angiotensin II and serotonin effect on vascular tone].

Pub. Date : 2011 Jan-Feb

PMID : 21446059






2 Functional Relationships(s)
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1 It has been shown that the agonist of 5HT1A-receptors 8-OH-DPAT induces contraction of aortic rings in the presence of angiotensin II. 8-Hydroxy-2-(di-n-propylamino)tetralin angiotensinogen Rattus norvegicus
2 This effect is not associated with activation of alpha1-adrenoceptors by 8-OH-DPAT as it is reproduced in the presence of prazosin which completely suppresses the nonspecific vasoconstrictive effect of 8-OH-DPAT via alpha1-adrenoceptors on the aorta incubated without angiotensin II. 8-Hydroxy-2-(di-n-propylamino)tetralin angiotensinogen Rattus norvegicus