Title : Replication inhibition activity of carbocycles related to oseltamivir on influenza A virus in vitro.

Pub. Date : 2011 Jun

PMID : 21443905






2 Functional Relationships(s)
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1 These results, together with the structures of these compounds, suggest that hydrogen-bonding interactions between the polar amino or guanidino functions and complementary groups in the neuraminidase active site (e.g. Asp151, Glu 119) may be essential for strong inhibition of the neuraminidase enzyme and, in turn, the inhibition of influenza A virus replication. Hydrogen neuraminidase 1 Homo sapiens
2 These results, together with the structures of these compounds, suggest that hydrogen-bonding interactions between the polar amino or guanidino functions and complementary groups in the neuraminidase active site (e.g. Asp151, Glu 119) may be essential for strong inhibition of the neuraminidase enzyme and, in turn, the inhibition of influenza A virus replication. Hydrogen neuraminidase 1 Homo sapiens