Title : CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).

Pub. Date : 2011 May 20

PMID : 21402692






3 Functional Relationships(s)
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1 CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+-)-14,15-epoxyeicosatrienoic acid (EET). 14,15-epoxy-5,8,11-eicosatrienoic acid cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+-)-14,15-epoxyeicosatrienoic acid (EET). 14,15-epoxy-5,8,11-eicosatrienoic acid cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 CYP3A4 was profiled for NADPH-dependent arachidonic acid (AA) metabolism and synthesized AA epoxygenase products (+-)-8,9-, (+-)-11,12-, and (+-)-14,15-epoxyeicosatrienoic acid (EET) (total turnover of ~2 pmol/pmol CYP3A4/min) but not hydroxylase products (+-)-15-, (+-)-19-, or 20-hydroxyeicosatetraenoic acid. 14,15-epoxy-5,8,11-eicosatrienoic acid cytochrome P450 family 3 subfamily A member 4 Homo sapiens