Pub. Date : 2011 May 20
PMID : 21402692
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+-)-14,15-epoxyeicosatrienoic acid (EET). | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (+-)-14,15-epoxyeicosatrienoic acid (EET). | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CYP3A4 was profiled for NADPH-dependent arachidonic acid (AA) metabolism and synthesized AA epoxygenase products (+-)-8,9-, (+-)-11,12-, and (+-)-14,15-epoxyeicosatrienoic acid (EET) (total turnover of ~2 pmol/pmol CYP3A4/min) but not hydroxylase products (+-)-15-, (+-)-19-, or 20-hydroxyeicosatetraenoic acid. | 14,15-epoxy-5,8,11-eicosatrienoic acid | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |