Title : Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages.

Pub. Date : 2011 Apr

PMID : 21395877






1 Functional Relationships(s)
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1 RESULTS: Budesonide and dexamethasone produced a concentration-dependent inhibition of the LPS-induced IL-8 and TNF-alpha secretion with an E(max) about 90% of inhibition, which was reduced by approximately 30% in the presence of H(2)O(2) or CSE. Budesonide C-X-C motif chemokine ligand 8 Homo sapiens