Pub. Date : 2011 May
PMID : 21395581
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We recently reported ATP induces the release of an unconventional 20-kDa form of IL-1beta (p20-IL-1beta) from lipopolysaccharide-primed microglial cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | We recently reported ATP induces the release of an unconventional 20-kDa form of IL-1beta (p20-IL-1beta) from lipopolysaccharide-primed microglial cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | Here, we investigated the pathways involved in the ATP-induced production of p20-IL-1beta using lipopolysaccharide-primed mouse microglial cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 4 | The activation of P2X7 receptor by ATP triggered p20-IL-1beta production under acidic extracellular conditions. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 5 | ATP-induced p20-IL-1beta production was blocked by pepstatin A, a potent inhibitor of the lysosomal protease, cathepsin D. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 6 | Since facilitation of pore dilatation results in cytolysis accompanied with cytoplasmic pro-IL-1beta leakage, our data suggest the leaked pro-IL-1beta is processed into p20-IL-1beta by cathepsin D released after ATP stimulation under acidic extracellular conditions. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 7 | Since facilitation of pore dilatation results in cytolysis accompanied with cytoplasmic pro-IL-1beta leakage, our data suggest the leaked pro-IL-1beta is processed into p20-IL-1beta by cathepsin D released after ATP stimulation under acidic extracellular conditions. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |