Pub. Date : 2011 Mar 15
PMID : 21392639
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Clopidogrel, a prodrug, requires hepatic cytochrome P450 (CYP) metabolic activation to produce the active metabolite that inhibits the platelet P2Y12 adenosine diphosphate (ADP) receptor, decreasing platelet activation and aggregation processes. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to competitively inhibit CYP activation of clopidogrel, reducing clopidogrel responsiveness. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | Atorvastatin, omeprazole, and several other drugs have been shown in pharmacodynamic studies to competitively inhibit CYP activation of clopidogrel, reducing clopidogrel responsiveness. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | Conversely, other agents increase clopidogrel responsiveness by inducing CYP activity. | Clopidogrel | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |