Title : Substitution of arginine for Leu444 in the reactive site of heparin cofactor II enhances the rate of thrombin inhibition.

Pub. Date : 1990 Apr 5

PMID : 2138609






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Dermatan sulfate accelerated thrombin inhibition by both forms of rHCII, but the maximum rate constant in the presence of dermatan sulfate was only 2-fold higher for rHCII(Leu444----Arg) (k2 = 5.3 x 10(8) M-1 min-1) than for native rHCII (k2 = 2.2 x 10(8) M-1 min-1). Dermatan Sulfate serpin family D member 1 Rattus norvegicus
2 Dermatan sulfate accelerated thrombin inhibition by both forms of rHCII, but the maximum rate constant in the presence of dermatan sulfate was only 2-fold higher for rHCII(Leu444----Arg) (k2 = 5.3 x 10(8) M-1 min-1) than for native rHCII (k2 = 2.2 x 10(8) M-1 min-1). Dermatan Sulfate serpin family D member 1 Rattus norvegicus
3 Heparin was less effective than dermatan sulfate in stimulating both forms of rHCII. Dermatan Sulfate serpin family D member 1 Rattus norvegicus