Title : Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies.

Pub. Date : 2011 Apr 1

PMID : 21383285






1 Functional Relationships(s)
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1 ARQ 197 decreased phosphorylated c-MET, total c-MET, and phosphorylated focal adhesion kinase and increased terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate-biotin nick-end labeling (TUNEL) staining in tumor biopsies (n = 15). Biotin DNA nucleotidylexotransferase Homo sapiens