Title : Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.

Pub. Date : 2011 Apr 29

PMID : 21378396






2 Functional Relationships(s)
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1 Examination of the phosphorylation of major MAPKs revealed that DFO and Dp44mT markedly increased phosphorylation of stress-activated protein kinases, JNK and p38, without significantly affecting the extracellular signal-regulated kinase (ERK). Deferoxamine mitogen-activated protein kinase 8 Homo sapiens
2 Iron or N-acetylcysteine supplementation reversed Dp44mT-induced up-regulation of phospho-JNK, but only iron was able to reverse the effect of DFO on JNK. Deferoxamine mitogen-activated protein kinase 8 Homo sapiens