Title : Humanized anti-Trop-2 IgG-SN-38 conjugate for effective treatment of diverse epithelial cancers: preclinical studies in human cancer xenograft models and monkeys.

Pub. Date : 2011 May 15

PMID : 21372224






1 Functional Relationships(s)
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1 Exposure of cells to the ADC demonstrated signaling pathways leading to PARP cleavage, but differences versus free SN-38 in p53 and p21 upregulation were noted. Irinotecan tumor protein p53 Homo sapiens