Title : In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed.

Pub. Date : 2011 May

PMID : 21371789






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, the interaction mode of SHMT with pemetrexed, an antifolate drug inhibiting several enzymes involved in folate-dependent biosynthetic pathways, was assessed. Folic Acid serine hydroxymethyltransferase 1 Homo sapiens