Title : Role of the JNK/c-Jun/AP-1 signaling pathway in galectin-1-induced T-cell death.

Pub. Date : 2010

PMID : 21364631






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Inhibition of JNK activation with sphingomyelinase inhibitors (20 muM desipramine, 20 muM imipramine), with the protein kinase C-delta (PKCdelta) inhibitor rottlerin (10 muM), and with the specific PKCtheta pseudosubstrate inhibitor (30 muM) indicates that ceramide and phosphorylation by PKCdelta and PKCtheta mediate gal-1-induced JNK activation. Ceramides mitogen-activated protein kinase 8 Homo sapiens