Title : [Design, synthesis and in vitro activity of glycinamide-bearing compounds as DPP-IV inhibitors].

Pub. Date : 2010 Nov

PMID : 21361038






2 Functional Relationships(s)
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1 To research the structure-activity relationship (SAR) of glycinamide-bearing compounds that used as inhibitors of dipeptidyl peptidase IV (DPP-IV), P32/98 and compound A were chosen as the leading compounds, heterocycles containing nitrogen atom were introduced to form amide, and different residues on a-position of carbonyl were designed. Amides dipeptidyl peptidase 4 Homo sapiens
2 To research the structure-activity relationship (SAR) of glycinamide-bearing compounds that used as inhibitors of dipeptidyl peptidase IV (DPP-IV), P32/98 and compound A were chosen as the leading compounds, heterocycles containing nitrogen atom were introduced to form amide, and different residues on a-position of carbonyl were designed. Amides dipeptidyl peptidase 4 Homo sapiens