Pub. Date : 2011 Mar
PMID : 21357734
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG channel. | Aminosalicylic Acid | ETS transcription factor ERG | Homo sapiens |
| 2 | A Per-Arnt-Sim (PAS) domain in the cytoplasmic N-terminal region of hERG regulates slow deactivation by making a direct interaction with another part of the hERG channel. | Aminosalicylic Acid | ETS transcription factor ERG | Homo sapiens |
| 3 | We report that hERG channels with deletions of the cyclic nucleotide-binding domain (CNBD) had accelerated deactivation kinetics that were similar to those seen in hERG channels lacking the PAS domain. | Aminosalicylic Acid | ETS transcription factor ERG | Homo sapiens |
| 4 | Together, these data suggest that the mechanism for regulation of slow deactivation in hERG channels is an interaction between the N-terminal PAS domain and the C-terminal CNBD. | Aminosalicylic Acid | ETS transcription factor ERG | Homo sapiens |