Title : Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds.

Pub. Date : 2011 Apr 29

PMID : 21357415






1 Functional Relationships(s)
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1 The aggressive pathogenic PS1 L166P mutation was one of the few pathogenic mutations that resisted GSM-1, and Leu-166 was identified as a critical residue with respect to the Abeta(42)-lowering response of GSM-1. Leucine GSM1 Homo sapiens