Pub. Date : 2011 Mar
PMID : 21356367
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | beta-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARgamma pathway. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 2 | Recently, the plant metabolite (E)-beta-caryophyllene (BCP) was shown to bind to and activate CB2. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 3 | Recently, the plant metabolite (E)-beta-caryophyllene (BCP) was shown to bind to and activate CB2. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 4 | The use of the CB2 antagonist AM630 or the PPARgamma antagonist GW9662 significantly reversed the protective effect of BCP. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |
| 5 | These results demonstrate that the anti-inflammatory effect of BCP involves CB2 and the PPARgamma pathway and suggest BCP as a possible therapy for the treatment of inflammatory bowel disease. | caryophyllene | cannabinoid receptor 2 (macrophage) | Mus musculus |