Pub. Date : 2011 May
PMID : 21354561
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | RESULT(S): Applying our cell culture model, we demonstrated that ATRA induced changes in the expression and activation of the RA and PI3K/Akt pathway proteins in leiomyoma cells, with significant increases of alcohol dehydrogenase 1 and cyclin D2 protein levels. | Tretinoin | AKT serine/threonine kinase 1 | Homo sapiens |