Title : All-trans-retinoic acid mediates changes in PI3K and retinoic acid signaling proteins of leiomyomas.

Pub. Date : 2011 May

PMID : 21354561






5 Functional Relationships(s)
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1 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin AKT serine/threonine kinase 1 Homo sapiens
2 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin AKT serine/threonine kinase 1 Homo sapiens
3 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin AKT serine/threonine kinase 1 Homo sapiens
4 OBJECTIVE: To detect changes induced by all-trans-retinoic acid (ATRA) on the expression and activation of target proteins of the retinoic acid (RA) and PI3K/Akt pathways involved in leiomyoma growth. Tretinoin AKT serine/threonine kinase 1 Homo sapiens
5 RESULT(S): Applying our cell culture model, we demonstrated that ATRA induced changes in the expression and activation of the RA and PI3K/Akt pathway proteins in leiomyoma cells, with significant increases of alcohol dehydrogenase 1 and cyclin D2 protein levels. Tretinoin AKT serine/threonine kinase 1 Homo sapiens