Title : Interrelationships of platelet-derived growth factor isoform-induced changes in c-fos expression, intracellular free calcium, and mitogenesis.

Pub. Date : 1990 Sep

PMID : 2135398






2 Functional Relationships(s)
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1 Concentration-dependent increases in [Ca2+]i, c-fos expression, and [3H]thymidine incorporation were observed with both BB and AA PDGF isoforms. boeravinone B Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Conversely, in cells made deficient in protein kinase C (PKC) activity by prolonged treatment with phorbol ester, BB and AA PDGF-induced c-fos expression was inhibited by 75-80%, while PDGF-induced increases in [Ca2+]i and DNA synthesis were unaffected or enhanced. boeravinone B Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens