Title : Peroxisome proliferator-activated receptor-γ stimulates 11β-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.

Pub. Date : 2011 May

PMID : 21352843






1 Functional Relationships(s)
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1 Using primary cultures of VSMC derived from rat aorta, we showed that pioglitazone significantly increases 11HSD1 activity and mRNA expression in a dose-dependent manner with EC(50) 243 nM and that this effect is not blocked by RU 486, an antagonist of the glucocorticoid receptor. Pioglitazone nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus