Pub. Date : 2011 Apr
PMID : 21352343
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cultured skin fibroblasts from patients with scleroderma were treated with RA and their effect on the expression of 5-lipoxygenase (LOX), transforming growth factor (TGF)-beta1, connective tissue growth factor (CTGF), type I and type III collagen was tested by reverse transcription polymerase chain reaction (RT-PCR) and western immunoblotting. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 2 | RA significantly inhibited the expression of 5-LOX and of TGF-beta1, CTGF, type I and type III collagen. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 3 | In vitro, RA reduced 5-LOX expression in scleroderma fibroblasts and downregulated TGF-beta1 and CTGF expression, leading to the inhibition of type I and type III collagen synthesis. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |
| 4 | Our results indicate that the clinical effects of RA on scleroderma are, at least in part, attributable to the reduction of 5-LOX expression and the subsequent suppression of TGF-beta1 and CTGF expression that results in the blockade of collagenogenesis. | Tretinoin | transforming growth factor beta 1 | Homo sapiens |