Pub. Date : 2011
PMID : 21346392
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicorandil inhibits angiotensin-II-induced proliferation of cultured rat cardiac fibroblasts. | Nicorandil | angiotensinogen | Rattus norvegicus |
| 2 | The aims of this study were to examine whether nicorandil may alter angiotensin-II (Ang II)-induced cell proliferation and to identify the putative underlying signaling pathways in rat cardiac fibroblasts. | Nicorandil | angiotensinogen | Rattus norvegicus |
| 3 | The aims of this study were to examine whether nicorandil may alter angiotensin-II (Ang II)-induced cell proliferation and to identify the putative underlying signaling pathways in rat cardiac fibroblasts. | Nicorandil | angiotensinogen | Rattus norvegicus |
| 4 | The effects of nicorandil on Ang-II-induced reactive oxygen species (ROS) formation and extracellular signal-regulated kinase (ERK) phosphorylation were also examined. | Nicorandil | angiotensinogen | Rattus norvegicus |
| 5 | RESULTS: Nicorandil (0.1-10 mumol/l) caused a concentration-dependent inhibition of Ang-II-increased cell proliferation and ET-1 expression which were prevented by the K(ATP) channel blocker glibenclamide (1 mumol/l). | Nicorandil | angiotensinogen | Rattus norvegicus |
| 6 | N-nitro-L-arginine methyl ester, an inhibitor of NOS, and the short interfering RNA transfection for eNOS markedly attenuated the inhibitory effect of nicorandil on Ang-II-induced cell proliferation. | Nicorandil | angiotensinogen | Rattus norvegicus |