Title : Determinants of TRPV4 activity following selective activation by small molecule agonist GSK1016790A.

Pub. Date : 2011 Feb 14

PMID : 21339821






2 Functional Relationships(s)
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1 GSK101 (10 nM) causes a TRPV4 specific Ca(2+) influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca(2+)-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization. Ruthenium Red transient receptor potential cation channel subfamily V member 4 Homo sapiens
2 GSK101 (10 nM) causes a TRPV4 specific Ca(2+) influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca(2+)-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization. Ruthenium Red transient receptor potential cation channel subfamily V member 4 Homo sapiens