Pub. Date : 2011 Apr 1
PMID : 21325074
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sunitinib, a potent inhibitor of RET, VEGF receptor (VEGFR)-1, VEGFR-2, VEGFR-3, and platelet-derived growth factor receptor (PDGFR)alpha/beta, has been reported as clinically effective in some patients with advanced MTC. | Sunitinib | ret proto-oncogene | Homo sapiens |
| 2 | EXPERIMENTAL DESIGN: Both in vitro and in vivo assays, using the human TT RET(C634W) MTC cell line, were done to assess the activity of sunitinib. | Sunitinib | ret proto-oncogene | Homo sapiens |
| 3 | RESULTS: Sunitinib displayed antiproliferative and antiangiogenic activities and inhibited RET autophosphorylation and activation of downstream signaling pathways. | Sunitinib | ret proto-oncogene | Homo sapiens |