Pub. Date : 2011 Mar
PMID : 21317532
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. | Niacin | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 2 | Surprisingly, transplantation of bone marrow from GPR109A-deficient mice into atherosclerosis-prone animals also abrogated the beneficial effect of nicotinic acid. | Niacin | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 3 | Furthermore, activation of GPR109A by nicotinic acid inhibited MCP-1-induced recruitment of macrophages into the peritoneal cavity and impaired macrophage recruitment to atherosclerotic plaques. | Niacin | hydroxycarboxylic acid receptor 2 | Mus musculus |
| 4 | In contrast with current models, our data show that nicotinic acid can reduce the progression of atherosclerosis independently of its lipid-modifying effects through the activation of GPR109A on immune cells. | Niacin | hydroxycarboxylic acid receptor 2 | Mus musculus |