Title : The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart.

Pub. Date : 2011 Aug

PMID : 21311897






3 Functional Relationships(s)
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1 BACKGROUND: The beta(1)-adrenoceptor (beta(1)AR) mediates cardiostimulatory effects of catecholamines in the heart. Catecholamines adrenoceptor beta 1 Homo sapiens
2 BACKGROUND: The beta(1)-adrenoceptor (beta(1)AR) mediates cardiostimulatory effects of catecholamines in the heart. Catecholamines adrenoceptor beta 1 Homo sapiens
3 The Arg389Gly polymorphism of the beta(1)AR gene has recently been shown to determine the responsiveness to catecholamines in vitro, and we previously reported that dobutamine induced an augmented contractile response in humans homozygous for the Arg389 allele. Catecholamines adrenoceptor beta 1 Homo sapiens