Title : Curcumin Induces Downregulation of E2F4 Expression and Apoptotic Cell Death in HCT116 Human Colon Cancer Cells; Involvement of Reactive Oxygen Species.

Pub. Date : 2010 Dec

PMID : 21311680






2 Functional Relationships(s)
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1 Expression of several genes, cyclin A, p21, and p27, which has been shown to be regulated in E2F4-dependent manner and involved in the cell cycle progression was also affected by curcumin. Curcumin H3 histone pseudogene 16 Homo sapiens
2 Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline. Curcumin H3 histone pseudogene 16 Homo sapiens