Title : Biological properties of androgen receptor pure antagonist for treatment of castration-resistant prostate cancer: optimization from lead compound to CH5137291.

Pub. Date : 2011 Sep

PMID : 21308717






1 Functional Relationships(s)
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1 We previously reported that a novel nonsteroidal AR pure antagonist, CH4933468, which is a thiohydantoin derivative with a sulfonamide side chain, provided in vitro proof of concept but did not in vivo. Sulfonamides androgen receptor Homo sapiens