Title : Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action.

Pub. Date : 2011 Jul

PMID : 21306580






2 Functional Relationships(s)
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1 Peritoneal mouse macrophages showed less ATP-induced permeabilization to ethidium bromide in the presence of colchicine, and less reactive oxygen species (ROS) formation, nitric oxide (NO) and interleukin (IL)-1beta release. Adenosine Triphosphate interleukin 1 beta Mus musculus
2 Finally, in vivo assays with mice inoculated with lipopolysaccharide and ATP showed diminished ROS, IL-1beta, interferon-gamma and NO production after colchicine treatment. Adenosine Triphosphate interleukin 1 beta Mus musculus