Title : MCT expression and lactate influx/efflux in tanycytes involved in glia-neuron metabolic interaction.

Pub. Date : 2011 Jan 28

PMID : 21297988






4 Functional Relationships(s)
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1 Using primary tanycyte cultures, kinetic analyses and sensitivity to inhibitors were undertaken to confirm that MCT1 and MCT4 were functional for lactate influx. Lactic Acid solute carrier family 16 member 3 Rattus norvegicus
2 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid solute carrier family 16 member 3 Rattus norvegicus
3 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid solute carrier family 16 member 3 Rattus norvegicus
4 Because the expression of both MCT1 and MCT4 has been linked to lactate efflux, we propose that tanycytes participate in glucose sensing based on a metabolic interaction with neurons of the arcuate nucleus, which are stimulated by lactate released from MCT1 and MCT4-expressing tanycytes. Lactic Acid solute carrier family 16 member 3 Rattus norvegicus