Title : Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site.

Pub. Date : 2011 Mar

PMID : 21284559






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively. Proline neuropeptide Y Homo sapiens
2 The specific activity of DP4 for neuropeptide Y (NPY) cleavage comprising a proline in P1-position is the same range as the k(cat)/K(m) values of NPY derivatives containing alanine or serine in P1-position with 4 x 105 M-1 s-1, 9.5 x 105 M-1 s-1 and 2.1 x 105 M-1 s-1, respectively. Proline neuropeptide Y Homo sapiens