Title : Pharmacokinetics for once-daily versus twice-daily tacrolimus formulations in de novo liver transplantation: a randomized, open-label trial.

Pub. Date : 2011 Feb

PMID : 21280190






4 Functional Relationships(s)
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Protein Name
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1 Tacrolimus, a cornerstone immunosuppressant, is available as a twice-daily formulation (tacrolimus bid). Tacrolimus BH3 interacting domain death agonist Homo sapiens
2 Tacrolimus, a cornerstone immunosuppressant, is available as a twice-daily formulation (tacrolimus bid). Tacrolimus BH3 interacting domain death agonist Homo sapiens
3 Tacrolimus area under the curve (AUC) from 0 to 24 hours (AUC(0-24) ) at equivalent doses was approximately 50% lower for tacrolimus qd than for bid on day 1 (146 versus 264 ng h/mL, respectively), but by day 14 was comparable between treatments (324 and 287 ng h/mL, respectively) with higher tacrolimus qd doses. Tacrolimus BH3 interacting domain death agonist Homo sapiens
4 There was a strong correlation between AUC(0-24) and concentration at 24 hours for tacrolimus qd and bid (r = 0.92 and r = 0.76, respectively). Tacrolimus BH3 interacting domain death agonist Homo sapiens