Title : Cigarette smoke extract regulates cytosolic phospholipase A2 expression via NADPH oxidase/MAPKs/AP-1 and p300 in human tracheal smooth muscle cells.

Pub. Date : 2011 Feb

PMID : 21268080






2 Functional Relationships(s)
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1 Moreover, CSE also induced c-Jun and c-Fos expression, which were inhibited by pretreatment with the inhibitors of NADPH oxidase (diphenyleneiodonium chloride and apocynin) and the ROS scavenger (N-acetyl-L-cysteine) or transfection with siRNAs of p47(phox) and NADPH oxidase (NOX)2. diphenyleneiodonium Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Furthermore, CSE-induced p300 and c-Jun complex formation was inhibited by pretreatment with diphenyleneiodonium chloride, apocynin, N-acetyl-L-cysteine or SP600125. diphenyleneiodonium Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens