Pub. Date : 2011 Feb
PMID : 21268072
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Gambogic acid-induced degradation of mutant p53 is mediated by proteasome and related to CHIP. | gambogic acid | tumor protein p53 | Homo sapiens |
| 2 | In the present study, we demonstrate that mutant p53 protein stability is regulated by gambogic acid (GA). | gambogic acid | tumor protein p53 | Homo sapiens |
| 3 | In the present study, we demonstrate that mutant p53 protein stability is regulated by gambogic acid (GA). | gambogic acid | tumor protein p53 | Homo sapiens |
| 4 | Following GA exposure, protein levels of mutant p53 decreased while the mRNA levels were not affected in MDA-MB-435 cells, which indicate that GA down-regulates mutant p53 at post-transcription level. | gambogic acid | tumor protein p53 | Homo sapiens |
| 5 | Following GA exposure, protein levels of mutant p53 decreased while the mRNA levels were not affected in MDA-MB-435 cells, which indicate that GA down-regulates mutant p53 at post-transcription level. | gambogic acid | tumor protein p53 | Homo sapiens |
| 6 | Co-treatment with GA and cycloheximide, a protein synthesis inhibitor, induced a decrease of half-life of mutant p53 protein. | gambogic acid | tumor protein p53 | Homo sapiens |
| 7 | These findings indicated that the reduction of mutant p53 by GA was due to the destabilization and degradation of the protein. | gambogic acid | tumor protein p53 | Homo sapiens |
| 8 | Furthermore, inhibition of proteasome activity by MG132 blocked GA-induced down-regulation of mutant p53, causing mutant p53 accumulation in detergent-insoluble cellular fractions. | gambogic acid | tumor protein p53 | Homo sapiens |
| 9 | Furthermore, inhibition of proteasome activity by MG132 blocked GA-induced down-regulation of mutant p53, causing mutant p53 accumulation in detergent-insoluble cellular fractions. | gambogic acid | tumor protein p53 | Homo sapiens |
| 10 | In addition, GA prevented Hsp90/mutant p53 complex formation and enhanced interaction of mutant p53 with Hsp70. | gambogic acid | tumor protein p53 | Homo sapiens |
| 11 | In addition, GA prevented Hsp90/mutant p53 complex formation and enhanced interaction of mutant p53 with Hsp70. | gambogic acid | tumor protein p53 | Homo sapiens |