Pub. Date : 2011 May 20
PMID : 21262221
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. | 3-methyladenine | tumor protein p53 | Homo sapiens |
2 | Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. | 3-methyladenine | tumor protein p53 | Homo sapiens |
3 | Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. | 3-methyladenine | tumor protein p53 | Homo sapiens |
4 | Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. | 3-methyladenine | tumor protein p53 | Homo sapiens |
5 | In addition, we also found that 3-MA efficiently abrogated silibinin"s cyto-protective effect against mitomycin C-induced cell death, and reversed the suppressive efficacy of silibinin on p53 expression, suggesting that autophagy contributed to silibinin"s cyto-protective effect against mitomycin C-induced cell death in A375-S2 cells. | 3-methyladenine | tumor protein p53 | Homo sapiens |