Title : Mechanism of autophagy induction and role of autophagy in antagonizing mitomycin C-induced cell apoptosis in silibinin treated human melanoma A375-S2 cells.

Pub. Date : 2011 May 20

PMID : 21262221






4 Functional Relationships(s)
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1 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine nuclear factor kappa B subunit 1 Homo sapiens
2 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine nuclear factor kappa B subunit 1 Homo sapiens
3 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine nuclear factor kappa B subunit 1 Homo sapiens
4 Autophagic specific inhibitor 3-methyladenine (3-MA) treatment reversed silibinin-induced p53 suppression as well as NF-kappaB activation, suggesting that there was a positive feedback loop between p53 inhibition-mediated NF-kappaB activation and autophagy. 3-methyladenine nuclear factor kappa B subunit 1 Homo sapiens