Pub. Date : 2011 Jan
PMID : 21261644
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | By a PD98059-inhibitable process, resveratrol causes inducible COX-2 to accumulate in the nucleus where it complexes with pERK1/2 and p53. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | NS-398, a specific pharmacologic inhibitor of COX-2, prevents resveratrol-induced complexing of nuclear ERK1/2 with COX-2 and with pSer-15-p53 and subsequent apoptosis; cyclooxygenase enzyme activity is not involved. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Molecular steps in the pro-apoptotic action of resveratrol in cancer cells include induction of intranuclear COX-2 accumulation relevant to activation of p53. | Resveratrol | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |