Title : Introduction of hypoxia-targeting p53 fusion protein for the selective therapy of non-small cell lung cancer.

Pub. Date : 2011 Jan 1

PMID : 21248471






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To develop an effective and low cytotoxic biological agent for targeted therapy, a p53 fusion protein, which was conjugated with the minimum motif of oxygen-dependent degradation domain (ODD) and the basic domain of TAT of HIV-1 named as TAT-ODD-p53, was evaluated for the treatment of NSCLC established by grafting H1299 cell line in which TP53 is homozygously deleted. Oxygen tumor protein p53 Homo sapiens