Pub. Date : 2011 Jan 11
PMID : 21224842
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sex-specific initiation of meiosis in the fetal ovary has been suggested to require retinoic acid (RA) for induction of Stra8, with expression of the RA-degrading enzyme Cyp26b1 in fetal testis delaying meiosis until postnatal development. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |
| 2 | Ketoconazole inhibition of Cyp26b1 in Raldh2(-/-) testis allows RA-independent induction of Stra8, but only when the mesonephros remains attached, pointing to a non-RA signal from the mesonephros that induces Stra8 in the adjacent gonad. | Tretinoin | cytochrome P450, family 26, subfamily b, polypeptide 1 | Mus musculus |