Title : Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.

Pub. Date : 2011 Feb 8

PMID : 21222484






1 Functional Relationships(s)
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1 5-Fluorouracil (5-FU), 5-fluorodeoxyuridine (5-dUrd), and raltitrixed (RTX) are anticancer agents that target thymidylate synthase (TS), thereby blocking the conversion of dUMP into dTMP. 2'-deoxyuridylic acid thymidylate synthetase Homo sapiens