Title : Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease.

Pub. Date : 2010 Dec 8

PMID : 21197068






2 Functional Relationships(s)
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1 It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Abeta plaques of the diseased brain can bind to Abeta and be linked to aggregation and neurotoxicity. Zinc amyloid beta precursor protein Homo sapiens
2 It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Abeta plaques of the diseased brain can bind to Abeta and be linked to aggregation and neurotoxicity. Zinc amyloid beta precursor protein Homo sapiens