Title : Imidazolylchromanone oxime ethers as potential anticonvulsant agents: Anticonvulsive evaluation in PTZ-kindling model of epilepsy and SAR study.

Pub. Date : 2011 Jan 15

PMID : 21195615






1 Functional Relationships(s)
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1 SAR studies showed that introduction of a chlorine atom to the 7-position and/or a methyl group to the 2-position of the chroman ring resulted in an improvement of anti-seizure efficacy in O-(2,4-dichlorobenzyl) oxime series. Chlorine sarcosine dehydrogenase Homo sapiens