Title : In vitro metabolism of jaceosidin and characterization of cytochrome P450 and UDP-glucuronosyltransferase enzymes in human liver microsomes.

Pub. Date : 2010 Dec

PMID : 21191764






1 Functional Relationships(s)
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1 CYP1A2 was identified as the major enzyme responsible for the formation of 6-O-desmethyljaceosidin and hydroxyjaceosidin from jaceosidin on the basis of a combination of correlation analysis and experiments including immuno-inhibition, chemical inhibition in human liver microsomes, and metabolism by human cDNA-expressed CYP enzymes. 6-o-desmethyljaceosidin cytochrome P450 family 1 subfamily A member 2 Homo sapiens